Downloaded from https://www.everyspec.com Biosafety level 2 (BSL–2) The facilities, equipment, and procedures applicable to clinical, diagnostic, or teaching laboratories, suitable for work involving indigenous agents of moderate potential hazard to personnel and the environment. It differs from BSL–1 in that— a. The laboratory personnel have specific training in handling pathogenic agents. b. The laboratory is directed by scientists with experience in the handling of specific agents. c. Access to the laboratory is limited when work is being conducted. d.
Certain procedures in which infectious aerosols could be created are conducted in biological safety cabinets or other physical containment equipment. e. Personnel must be trained. f. Strict adherence to recommended practices is as important in attaining the maximum containment capability, as is the mechanical performance of the equipment itself. Biosafety level 3 (BSL–3) The facilities, equipment, and procedures applicable to clinical, diagnostic, research, production facilities in which work is performed with indigenous or exotic agents where there is potential for infection by aerosol and the disease may have serious or lethal consequences.
It differs from BSL–2 in that— More extensive training in handing pathogenic and potentially lethal agents is necessary for laboratory personnel. All procedures involving the manipulation of infectious material are conducted within biological safety cabinets or by other physical containment devices. The laboratory has special engineering and design features, including access zones, sealed penetrations, and directional airflow. Any modification of BSL–3 recommendations must be made only by the commander or director.
Biosafety level 4 (BSL–4) The facilities, equipment, and procedures required for work with dangerous and exotic agents that pose a high individual risk of life-threatening disease. It differs from BSL–3 in that— a. Members of the laboratory staff have specific and thorough training in handling extremely hazardous infectious agents. b. Laboratory personnel understand the primary and secondary containment functions of the standard and special practices, containment equipment, and laboratory design characteristics. c. Access to the laboratory is strictly controlled by the commander or director. d.
The facility is either in a separate building or in a controlled area within a building, which is completely isolated from all other areas of the building. e. A specific facility operations manual is prepared or adopted. f. Within work areas of the facility, all activities are confined to Class III biological safety cabinets or Class I or Class II biological safety cabinets used together with one-piece positive pressure personnel suits ventilated by a life- support system. g. The maximum containment laboratory has special engineering and design features to prevent microorganisms from being disseminated to the environment.
Blister agent A chemical agent that injures the eyes, lungs, and burns or blisters the skin. Business plan A comprehensive document that clearly describes how the safety office intends to obtain their strategic goals and objectives. It describes how they will execute their programs and processes, manage funding and manpower, and interface with other organizations to achieve those goals. Chemical agent A chemical compound intended for use (to include experimental compounds) in military operations to kill, seriously injure, or incapacitate persons through its physiological effects.
Excluded are RDT&E solutions, riot control agents, chemical defoliants and herbicides, smoke, flame and incendiaries, and industrial chemicals. Chemical agent operation Any operation that involves chemical agents, including storage, shipping, handling, manufacturing, maintenance, test chamber activities, laboratory activities, surveillance, demilitarization, decontamination, disposal, and training. 109 AR 385–10 • 23 August 2007